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Low ovarian reserve caused infertility, successfully conceived through ICSI with Dr. Ton


24 March 2025
Success Stories

Low ovarian reserve, a cause of infertility, successfully treated with ICSI by Dr. Ton, leading to a successful pregnancy

This patient had been trying to conceive naturally for many years but started to worry because many of their relatives and people around them also faced fertility issues. This concern led them to seek a medical evaluation at Beyond IVF.

The test results showed that the male partner was completely normal. However, when Dr. Ton performed an internal ultrasound on the female partner to examine her ovaries, he found only five antral follicles combined from both ovaries, which is significantly lower than the normal range for her age. This condition could make natural conception even more difficult.

Despite this, there was a silver lining. While the antral follicle count (AFC) was low, her AMH (Anti-Mullerian Hormone) levels—which indicate ovarian function—were still within the normal range, meaning her egg quality remained good. Given this, Dr. Ton advised that she could start fertility treatment immediately. However, he recommended the ICSI (Intracytoplasmic Sperm Injection) procedure, as it would be more effective than IUI (Intrauterine Insemination) for her case. Since both ovaries required stimulation, using injectable medications would be more effective than oral stimulation drugs. If her ovaries responded well, they could potentially retrieve more eggs than the five follicles seen on the ultrasound.

Starting the ICSI Journey

After discussing the options, the couple decided to proceed with ICSI to maximize their chances of conception as quickly as possible. On the second day of her menstrual cycle, the patient started the treatment process.

As expected, her ovaries responded well to the stimulation medication. The ultrasound revealed a total of 17 mature eggs, significantly more than initially anticipated. The retrieved eggs were then fertilized and developed into Blastocyst-stage embryos, which were screened using NGS (Next-Generation Sequencing) to check for chromosomal abnormalities.

The results showed that five embryos were chromosomally normal and viable for transfer. This case proved that despite having a low antral follicle count, as long as AMH levels are within the normal range, there is still a high chance of a successful pregnancy.

Dr. Ton selected the highest-quality embryo for transfer, and the patient successfully conceived.

Treatment Method: ICSI (Intracytoplasmic Sperm Injection)

ICSI: A specialized technique using a high-powered microscope to inject a single sperm directly into an egg, increasing fertilization success rates.
NGS: Chromosomal screening to ensure embryos are free from genetic abnormalities before implantation.

Patient's Experience with Beyond IVF

"Dr. Ton is truly amazing! He explained every step of the treatment so thoroughly that we felt completely confident in choosing Beyond IVF."

"A huge thank you to the entire Beyond IVF team—nurses, embryologists, and especially Dr. Ton—for taking such excellent care of us throughout this journey.


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The Biological Clock

This tool indicates:

  • Natural conception per month if you have no fertility issues
  • IVF success rate at the same age
  • When to seek help after months of unsuccessful attempts

If you are concerned at any stage – we recommend booking a doctor appointment or a free nurse consultation. The sooner you make a plan the better your chances in the long term.

When to seek advice early

  • If you have polycystic ovaries, endometriosis, or have been through a cancer diagnosis; we recommend you get in touch quickly so we can talk you through all your options and give you the greatest possible chance of success.
  • If you’re a single woman considering motherhood in the future; it’s best to approach us early and consider egg freezing as this can be an option for you while you have a higher ovarian reserve and healthier eggs.
Set your age and the months you’ve been trying to conceive
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Your chance of having a baby per month for fertile couples
Your chance of having a baby per IVF cycle (if experiencing infertility)

Body Mass Index calculator

Being overweight or underweight can reduce fertility, so it is important to keep your body weight within the normal healthy range.

Body Mass Index (BMI) is an indication of your body weight and can be calculated by dividing weight by height. You should aim for a BMI of between 20 and 25, as this will optimise your chances of conception.

Woman’s BMI below 19

Even in these modern times, nature knows best. If a woman's BMI falls below 19, the body senses famine and ovulation is switched off to prevent the risk of having a baby with malnutrition. Excessive exercise can reduce body fat and increase muscle mass to a point where periods cease for the same reason. Risk of miscarriage is also increased in women with a low BMI.

Being underweight

If a woman's BMI falls below 19, the body senses famine and ovulation is switched off to prevent the risk of having a baby with malnutrition. Excessive exercise can reduce body fat and increase muscle mass to a point where periods cease for the same reason. Risk of miscarriage is also increased in women with a low BMI.

BMI’s greater than 30

This can reduce fertility by 50%. Pregnancy for women with a 30+ BMI is often associated with problems such as maternal diabetes, high blood pressure, big babies and increased risk of caesarean section.

Add your height and weight to calculate your BMI